منابع مشابه
Bioavailability of bacampicillin and talampicillin, two oral prodrugs of ampicillin.
A 200-mg amount of bacampicillin showed a significantly higher relative extent of bioavailability than did a 250-mg amount of talampicillin, possibly due to their different stability in the digestive juices.
متن کاملTalampicillin: a new derivative of ampicillin.
Talampicillin is a thiazolide carboxylic ester of ampicillin and is hydrolysed in the intestinal mucosa to release free ampicillin. The mean peak serum concentration of ampicillin occurred one hour after a dose of talampicillin and was about twice that attained by an equivalent dose of ampicillin. The presence of food in the stomach reduced and delayed the peak blood levels but did not affect t...
متن کاملOral talampicillin in the treatment of gonorrhoea.
Talampicillin was effective in eradicating the causitive organism in uncomplicated gonorrhoea, with only four treatment failures (1-6%) in 245 patients seen at least once after treatment. Symptoms, such as discharge, were seen in 61 patients at some stage after treatment but 31 of these cases were clear after one or two follow-up visits. The anitbiotic was well tolerated. One patient developed ...
متن کاملBRL.8988 (talampicillin), a well-absorbed oral form of ampicillin.
The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.
متن کاملBlood Levels and and Distribution of Bacampicillin inNZW Talampicillin Rabbits
Parameters for blood concentrations of thc peroral antibiotics talampicil in and bacampicillin, in NZW rabbirs were deteTrnined using a two compartment model. On the basis of thesc pharmacokinetic parameters, a three compartment model was prepared for the concentrations of thcse drugs in the tongue, gingiva, submandibular gland, parotid gland, cervical 17mphnode and mandibular bone. Simulation ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6081.232-a